Awkward Family Holidays? Can Your High Just Be Gone? THCV and the CB1 Receptor
THCV is almost identical to THC in structure, but has a different effects profile. Instead of activating the CB1 receptor, THCV just sits on the receptor, blocking it from becoming active. This results in a reduction of CB1 receptor activity. There’s early preliminary evidence that THCV can reduce the effects of negative effects of THC. Read more to see you can help us find out!
THC (top left, white molecule) and THCV (top right, blue molecule) docked to the CB1 receptor. The two molecules are positioned in the binding pocket differently which affects its interaction with an important tryptophan residue that controls activation called the tryptophan switch.
Worried you’ll be uncomfortable around your family, especially after your “special walk”? THCV might be the answer.
The world of cannabis is filled with a variety of compounds called cannabinoids, each with its own unique effects. While THC and CBD are the most well-known, there is a growing interest in "minor cannabinoids" like tetrahydrocannabivarin (THCV). THCV, found in African Sativa strains like Durban Poison, has properties that set it apart from other cannabinoids, making it a rising star in the cannabis industry.
One of THCV's most fascinating aspects is its interaction with the CB1 receptor in the brain. Unlike THC, which activates the CB1 receptor and can lead to psychoactive effects, THCV acts as a neutral antagonist at the CB1 receptor. This means that THCV blocks the binding of THC at the receptor. This reduces the level of activation of the CB1 receptor, potentially reducing the intensity of the "high" associated with cannabis.
Research suggests that this unique interaction with the CB1 receptor may make THCV a promising candidate for addressing issues related to overconsumption of cannabis. Some individuals find that consuming too much cannabis can lead to unpleasant experiences like anxiety, paranoia, heart palpitations, induced hypothermia. Products containing THCV are being developed to help mitigate these negative effects by counteracting THC's action on the CB1 receptor.
The potential benefits of THCV's neutral antagonism at the CB1 receptor go beyond addressing negative experiences. Research on THCV suggests that it may have a variety of other therapeutic applications, including:
Obesity: THCV has been studied for its potential in treating obesity, as it may help regulate appetite and reduce food cravings
Mood Disorders: Preliminary studies indicate that THCV might have mood-boosting properties without the negative side effects associated with some other cannabinoids
Cognitive Function: Some researchers believe that THCV could play a role in enhancing cognitive function and focus, potentially benefiting individuals with attention-related challenges
While research on THCV is still ongoing, its distinctive properties and potential benefits are attracting attention from both the scientific community and the cannabis industry. As we learn more about this intriguing cannabinoid, it is likely to become even more prominent in the future.
Ready to experience the unique effects of THCV for yourself? Help us figure out if THCV helps reduce the effects of THC.